Open AccessDrug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis
Author(s) -
Vincenzo Puro,
Fabio Soldani,
Gabriella De Carli,
Zlatan Lazarevic,
Francesca Mattioli,
Giuseppe Ippolito
Publication year - 2003
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200309050-00020
Subject(s) - pre exposure prophylaxis , medicine , human immunodeficiency virus (hiv) , drug , antiretroviral drug , sida , lentivirus , antiretroviral agents , pharmacology , antiretroviral therapy , viral disease , virology , viral load , syphilis , men who have sex with men
In 655 individuals receiving HIV postexposure prophylaxis (PEP), drug-induced aminotransferase alterations were frequent and severe in the nevirapine-including regimen, rare and mild-to-moderate in other combinations, and always reversible. Grade 3-4 incidence in protease inhibitor or nevirapine PEP was 0.5 and 25.0 per 100 person-months, respectively. Apart from nevirapine, continuing PEP appears to be safe even in the case of aminotransferase alterations. The usefulness of routine monitoring of liver function during PEP could be re-considered.