Open AccessPlatelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV
Author(s) -
Tomasz Rozmysłowicz,
Marcin Majka,
J. Kijowski,
Samuel L. Murphy,
Dareus O. Conover,
Mortimer Poncz,
Janina Ratajczak,
Glen N. Gaulton,
Mariusz Z. Ratajczak
Publication year - 2003
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200301030-00006
Subject(s) - megakaryocyte , cxcr4 , haematopoiesis , biology , null cell , platelet , receptor , microbiology and biotechnology , virology , immunology , cell culture , stem cell , biochemistry , genetics , chemokine
Under some circumstances the HIV virus may infect cells that do not express receptors essential to HIV-entry. We hypothesized that platelet- and megakaryocyte-derived microparticles (MP) could play a role in such infections. MP are circular membrane fragments shed from the surface of eukaryotic cells. After adhesion to target cells, MP may transfer membrane-associated proteins to these cells. We found that peripheral blood platelet- (PMP) and megakaryocyte-derived MP (MegaMP) that highly express CXCR4 may transfer this receptor from the surface of platelets or megakaryocytes to the surface of CXCR4-null cells.