Open AccessMinimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients
Author(s) -
Xu Li,
Stéphane Hué,
Stephen Taylor,
Denise Ratcliffe,
Judith Workman,
Susan Jackson,
Patricia A. Cane,
Deenan Pillay
Publication year - 2002
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200208160-00016
Subject(s) - human immunodeficiency virus (hiv) , medicine , variation (astronomy) , antiretroviral therapy , sida , virology , immunology , viral disease , viral load , physics , astrophysics
In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.