Open AccessLiver toxicity caused by nevirapine
Author(s) -
Daniel Gonzàlez de Requena,
Mariúñez,
Inmaculada Jiménez-Nácher,
Vincent Soriano
Publication year - 2002
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200201250-00020
Subject(s) - nevirapine , toxicity , medicine , aspartate transaminase , transaminase , hepatitis , alanine transaminase , chronic hepatitis , gastroenterology , pharmacology , immunology , human immunodeficiency virus (hiv) , biology , virus , viral load , antiretroviral therapy , biochemistry , alkaline phosphatase , enzyme
Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 microg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.