Open AccessDirect analysis of mitochondrial toxicity of antiretroviral drugs
Author(s) -
Andrea Foli,
Federica Benvenuto,
Giampiero Piccinini,
Antonella Bareggi,
Andrea Cossarizza,
Julianna Lisziewicz,
Lori S. Friedman
Publication year - 2001
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200109070-00012
Subject(s) - mitochondrial toxicity , toxicity , didanosine , pharmacology , in vivo , reverse transcriptase inhibitor , mitochondrion , biology , chemistry , biochemistry , reverse transcriptase , virology , viral load , antiretroviral therapy , human immunodeficiency virus (hiv) , rna , microbiology and biotechnology , organic chemistry , gene
Mitochondrial toxicity is a serious side-effect of antiretroviral drugs, especially nucleoside reverse transcriptase inhibitors (NRTI). An in vitro assay to predict mitochondrial toxicity of in-use and developmental NRTI would be invaluable. To test the ability of a cytofluorimetric technique to predict the mitochondrial-dependent pancreatic and hepatic toxicity we used didanosine (ddI) alone or in combination with hydroxyurea (HU).