Mutations of the 3′ untranslated region of the SDF1 gene in apes and monkeys: potential impact on sensitivity to AIDS induced by lentiviruses | Zendy

Bénédicte PuissantLubrano | Zendy; Antoine Blancher | Zendy

Open Access

Mutations of the 3′ untranslated region of the SDF1 gene in apes and monkeys: potential impact on sensitivity to AIDS induced by lentiviruses

Author(s) -

Bénédicte PuissantLubrano,

Antoine Blancher

Publication year - 2001

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/00002030-200107060-00016

Subject(s) - gene , genetics , biology , untranslated region , virology , three prime untranslated region , lentivirus , mutation , virus , viral disease , messenger rna

The comparison of the stromal cell-derived factor-1 (SDF1) gene 3' untranslated region (3'UTR) of four great ape and four monkey species with their human counterparts shows that the human SDF1-3'A mutation is present in primate species that are the most susceptible to lentivirus-induced AIDS and is absent in species that are particularly resistant to lentivirus-induced AIDS. The results enlighten the possible relationship between SDF1-3'UTR polymorphism and sensitivity to AIDS.

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