Open AccessModulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors
Author(s) -
Louise Profit,
Victoria A. Eagling,
David Back
Publication year - 1999
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-199909100-00004
Subject(s) - saquinavir , p glycoprotein , nelfinavir , indinavir , caco 2 , ritonavir , efflux , amprenavir , chemistry , protease , protease inhibitor (pharmacology) , microbiology and biotechnology , pharmacology , biochemistry , biology , in vitro , hiv 1 protease , immunology , multiple drug resistance , virus , sida , viral disease , viral load , antiretroviral therapy , enzyme , antibiotics
To determine the effect of the protease inhibitors ritonavir, nelfinavir and indinavir on the P-glycoprotein (P-gp)-mediated transport of saquinavir in Caco-2 cell monolayers. To study the modulation of P-gp function in human lymphocytes by saquinavir, ritonavir, nelfinavir and indinavir.