Open AccessSafety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen
Author(s) -
John A. Bartlett,
Steven S. Wasserman,
Charles B. Hicks,
Robert T. Dodge,
Kent J. Weinhold,
Carol O. Tacket,
Nzeera Ketter,
Alec E. Wittek,
Thomas J. Palker,
Barton F. Haynes
Publication year - 1998
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-199811000-00010
Subject(s) - immunogen , immunogenicity , epitope , virology , immunology , adjuvant , medicine , peripheral blood mononuclear cell , antibody , biology , monoclonal antibody , in vitro , biochemistry
To evaluate the safety and immunogenicity of a polyvalent (PV) HIV envelope synthetic peptide immunogen, C4-V3. The immunogen comprised four peptides containing T-helper epitopes from the fourth constant region (C4) of gp120 of HIV-1MN, and T-helper, cytotoxic T-lymphocyte HLA-B7-restricted, and B-cell neutralizing epitopes from the gp120 third variable region (V3) of four clade B HIV-1 isolates, HIV-1MN, HIV-1RF, HIV-1EV91, and HIV-1Can0A.