Open AccessMaternal Caffeine Intake and Intrauterine Growth Retardation
Author(s) -
Laura M. Grosso,
Kenneth D. Rosenberg,
Kathleen Belanger,
Audrey F. Saftlas,
Brian P. Leaderer,
Michael B. Bracken
Publication year - 2001
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/00001648-200107000-00015
Subject(s) - caffeine , odds ratio , medicine , confidence interval , pregnancy , obstetrics , fetus , fetal growth , physiology , biology , genetics
This study estimates the effect of maternal caffeine consumption throughout pregnancy on fetal growth. We studied 2,714 women who delivered a liveborn infant between 1988 and 1991. Detailed information regarding coffee, tea, and soda drinking during the first and third trimesters of pregnancy was obtained. Average caffeine intake during month 1 of pregnancy was higher than for month 7 (72.4 vs 54.0 mg per day). Consumption of >300 mg caffeine per day during month 1 (adjusted odds ratio = 0.91; 95% confidence interval = 0.44--1.90) and during month 7 (adjusted odds ratio = 1.00; 95% confidence interval = 0.37--2.70) was not associated with intrauterine growth retardation. There was little evidence for any effect modification due to cigarette smoking on the caffeine associations. This study provides evidence that antenatal caffeine consumption has no adverse effect on fetal growth.