Open AccessLag Time between Stress Events and Risk of Recurrent Episodes of Inflammatory Bowel Disease
Author(s) -
Duffy Lc,
Zielezny Ma,
; Marshall,
Weiser Mm,
Phillips Jf,
Byers Te,
Calkins Bm,
Saxon Graham,
Ogra Pl
Publication year - 1991
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/00001648-199103000-00009
Subject(s) - medicine , disease , inflammatory bowel disease , cohort , lag time , cohort study , lag , relative risk , confidence interval , biology , biological system , computer network , computer science
We followed a cohort of 124 subjects with a history of inflammatory bowel disease to ascertain risk estimates for clinically active disease associated with exposure to recent stress events. We calculated risk estimates for three lag models (-1, 0, + 1 month). The data indicated a strong association between stress exposures and new clinical episodes of disease (RR = 2.9, 95% Cl: 2.0-4.1), most apparent in the immediate period (lag = 0). Risk estimates were also elevated for extended episodes of disease in subjects under stress compared with unexposed subjects. These results underscore the importance of monitoring stress exposures in prevention and treatment of recurrent disease.