Open AccessCostimulatory approaches to adoptive immunotherapy
Author(s) -
David Liebowitz,
Kelvin P. Lee,
Carl H. June
Publication year - 1998
Publication title -
current opinion in oncology/current opinion in oncology, with cancerlit
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 95
eISSN - 1080-8140
pISSN - 1040-8746
DOI - 10.1097/00001622-199811000-00010
Subject(s) - medicine , adoptive immunotherapy , immunotherapy , cancer immunotherapy , effector , immunology , t cell , ex vivo , adoptive cell transfer , immune system , cancer research , in vivo , biology , microbiology and biotechnology
Costimulation is critical for induction of full T-cell effector function, and thus represents an attractive immunotherapeutic approach for the treatment of cancer. This review examines these approaches, including ex vivo T-cell expansion, systemic "delivery" of constimulation, tumors transduced or transfected with costimulatory ligands, and vaccine strategies using coimmunization with the genes for costimulatory ligands. Impressive results in animal models have been demonstrated and a wide range of human clinical trials are underway.