Open AccessReticuloendothelial System Blockade Promotes Progression from Mild to Severe Acute Pancreatitis in the Opossum
Author(s) -
Christina Schleicher,
Jens C. Baas,
H. Elser,
N. Senninger
Publication year - 2001
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-200104000-00008
Subject(s) - medicine , pancreatitis , gastroenterology , acute pancreatitis , blockade , pathogenesis , pancreatic disease , hyperamylasemia , pancreatic duct , pancreas , amylase , endocrinology , enzyme , biology , receptor , biochemistry
To examine the relation between hepatic reticuloendothelial system (RES) dysfunction and the development of acute biliary pancreatitis. In an opossum model, the authors tested the hypothesis that RES blockade can turn the mild pancreatitis seen after pancreatic duct obstruction (PDO) into the severe form.