Open AccessModulation of JNK and p38 Stress Activated Protein Kinases In Isolated Islets of Langerhans
Author(s) -
Steven Paraskevas,
Reid Aikin,
Dušica Maysinger,
Jonathan R.T. Lakey,
Thomas J. Cavanagh,
Despina Agapitos,
Rennian Wang,
Lawrence Rosenberg
Publication year - 2001
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-200101000-00018
Subject(s) - p38 mitogen activated protein kinases , islet , tunel assay , apoptosis , medicine , cytokine , tumor necrosis factor alpha , kinase , insulin , endocrinology , protein kinase a , microbiology and biotechnology , biology , biochemistry , immunohistochemistry
The objective of this study was to determine the effects of islet isolation and cytokine exposure on e-JUN NH2 terminal kinase (JNK) and p38 activation and whether insulin or the p38 inhibitor PD169316 could modify the response.