Open AccessIncreased Small Bowel Epithelial Turnover in Interleukin-1 Receptor Knockout Mice
Author(s) -
Steven E. Wolf,
Meelie DebRoy,
Hiroto Ikeda,
Marc G. Jeschke,
Sina Matin,
Srinivasan Rajaraman,
Tien C. Ko,
Ella W. Englander,
James Norman,
James C. Thompson
Publication year - 2000
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-200007000-00006
Subject(s) - apoptosis , tunel assay , receptor , knockout mouse , endocrinology , cytokine , medicine , proinflammatory cytokine , biology , interleukin , intestinal mucosa , immunology , microbiology and biotechnology , pathology , immunohistochemistry , inflammation , biochemistry
To determine whether interleukin-1 (IL-1) affects the cellular homeostasis of small bowel mucosa, the authors studied apoptosis and proliferation in small bowel epithelium in two groups of C57 mice: an IL-1 receptor knockout group, and a control wild-type group.