Open AccessAngiotensin II Inhibitor DuP753 Attenuates Burn- and Endotoxin-Induced Gut Ischemia, Lipid Peroxidation, Mucosal Permeability, and Bacterial Translocation
Author(s) -
Tamer Tadros,
Daniel L. Traber,
John P. Heggers,
David N. Herndon
Publication year - 2000
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-200004000-00017
Subject(s) - medicine , total body surface area , superior mesenteric artery , intestinal permeability , hemodynamics , splanchnic , angiotensin ii , sepsis , anesthesia , blood pressure
To investigate the role of angiotensin II as a mediator of burn- and sepsis-induced gut ischemia and reperfusion injury and to determine whether treatment with the angiotensin II inhibitor DuP753 can attenuate mucosal injury and bacterial translocation in a burn/endotoxemia porcine model.