Open AccessInjury Induces Deficient Interleukin-12 Production, But Interleukin-12 Therapy After Injury Restores Resistance to Infection
Author(s) -
Andreas Göebel,
Eamon Kavanagh,
Ann Lyons,
Inna B. Saporoschetz,
Christopher C. Soberg,
James A. Lederer,
John A. Mannick,
Mary L. Rodrick
Publication year - 2000
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-200002000-00015
Subject(s) - medicine , peripheral blood mononuclear cell , burn injury , interleukin , immunology , lipopolysaccharide , lymphocyte , cytokine , surgery , in vitro , biochemistry , chemistry
To assess at serial intervals the production of interleukin-12 (IL-12) by monocytes/macrophages from the peripheral blood of injured patients and control subjects, and using a mouse model to confirm human findings and explore the effectiveness of low-dose IL-12 therapy in restoring resistance to infection after injury.