Open AccessEarly Activation of Hepatic NFκB and NF-IL6 in Polymicrobial Sepsis Correlates With Bacteremia, Cytokine Expression, and Mortality
Author(s) -
David L. Williams,
Tuanzhu Ha,
Chuanfu Li,
John H. Kalbfleisch,
Donald Ferguson
Publication year - 1999
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199907000-00014
Subject(s) - sepsis , bacteroides fragilis , medicine , cytokine , bacteremia , interleukin 6 , pathophysiology , tumor necrosis factor alpha , immunology , biology , microbiology and biotechnology , antibiotics
The role of transcription factor activation in the pathophysiology of sepsis syndrome has not been established. This study investigated the relation between tissue nuclear factor kappaB (NFkappaB) and nuclear factor interleukin 6 (NF-IL6 or C/EBP) activation and bacteremia, inflammatory cytokine expression, and mortality in a murine model of cecal ligation and puncture (CLP).