Open AccessPhospholipase A2 Mediates Nitric Oxide Production by Alveolar Macrophages and Acute Lung Injury in Pancreatitis
Author(s) -
Yasuhiro Tsukahara,
T. Morisaki,
Yoshiyuki Horita,
Motomichi Torisu,
Masao Tanaka
Publication year - 1999
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199903000-00012
Subject(s) - medicine , nitric oxide , acute pancreatitis , lung , pancreatitis , pathology
Reportedly, nitric oxide (NO) derived from alveolar macrophages (AMs) and increased serum phospholipase A2 (PLA2) activity are associated with the pathogenesis of lung injury in acute pancreatitis. The authors examined the possibility that PLA2 causes, in part, the induction of NO production by AMs in pancreatitis.