Open AccessGut-Derived Mesenteric Lymph but not Portal Blood Increases Endothelial Cell Permeability and Promotes Lung Injury After Hemorrhagic Shock
Author(s) -
Louis J. Magnotti,
Jeffrey S. Upperman,
Dazhong Xu,
Quan Lu,
Edwin A. Deitch
Publication year - 1998
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199810000-00008
Subject(s) - medicine , lymph , lymphatic system , shock (circulatory) , lung , pathology , vascular permeability , septic shock , evans blue , sepsis , immunology
To determine whether gut-derived factors leading to organ injury and increased endothelial cell permeability would be present in the mesenteric lymph at higher levels than in the portal blood of rats subjected to hemorrhagic shock. This hypothesis was tested by examining the effect of portal blood plasma and mesenteric lymph on endothelial cell monolayers and the interruption of mesenteric lymph flow on shock-induced lung injury.