Open AccessReduction of Hepatic Ischemia/Reperfusion Injury by a Soluble P-Selectin Glycoprotein Ligand-1
Author(s) -
T S Dulkanchainun,
John A. Goss,
David K. Imagawa,
Gray D. Shaw,
Dean M. Anselmo,
Fady M. Kaldas,
Tao Wang,
Delai Zhao,
Ashley Busuttil,
Hirohisa Kato,
Natalie Murray,
Jerzy W. KupiecWeglinski,
Ronald W. Busuttil
Publication year - 1998
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199806000-00006
Subject(s) - isograft , medicine , selectin , reperfusion injury , ischemia , p selectin , liver transplantation , blockade , transplantation , ex vivo , viaspan , tumor necrosis factor alpha , immunology , inflammation , pharmacology , in vivo , platelet , receptor , platelet activation , biology , microbiology and biotechnology
The authors' goal was to determine the effects of specific binding and blockade of P- and E-selectins by a soluble P-selectin glycoprotein ligand-1 (PSGL-1) in rat models of hepatic in vivo warm ischemia and ex vivo cold ischemia. The authors also sought to determine the effect of selectin blockade on isograft survival in a syngeneic rat orthotopic liver transplant model.