Open AccessAPC Genotype, Polyp Number, and Surgical Options in Familial Adenomatous Polyposis
Author(s) -
James S. Wu,
Philip Paul,
Ellen McGan,
James M. Church
Publication year - 1998
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199801000-00009
Subject(s) - medicine , familial adenomatous polyposis , genotype , adenomatous polyposis coli , adenomatous polyps , general surgery , gastroenterology , colorectal cancer , genetics , colonoscopy , cancer , gene , biology
This study was performed to examine the relation between phenotypic expression in patients with familial adenomatous polyposis (FAP) and the site of mutations in the APC (adenomatous polyposis coli) gene. The ability of APC mutations to predict surgical outcome was also investigated.