Open AccessPancreatic reg Gene Expression Is Inhibited During Cellular Differentiation
Author(s) -
Michael E. Zenilman,
Thomas Magnuson,
Riccardo Perfetti,
Jian Chen,
Alan R. Shuldiner
Publication year - 1997
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199703000-00013
Subject(s) - gene expression , cellular differentiation , endocrinology , cell culture , cholecystokinin , medicine , messenger rna , gastrin , glucagon , regulation of gene expression , biology , elastase , microbiology and biotechnology , hormone , receptor , gene , enzyme , biochemistry , genetics , secretion
Factors that control pancreatic regenerating (reg I) gene expression are unknown, but it is believed that its expression may correspond with cellular differentiation. The authors recently demonstrated that reg I is expressed in AR42J, a rat acinar cell line whose state of differentiation can be modulated by dexamethasone. They used this line to study reg I expression during cellular proliferation and differentiation.