Open AccessThe Ubiquitin-Proteasome Pathway
Author(s) -
Per-Olof Hasselgren,
Josef E. Fischer
Publication year - 1997
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199703000-00011
Subject(s) - proteasome , ubiquitin , catabolism , proteolysis , medicine , protein degradation , microbiology and biotechnology , biochemistry , enzyme , biology , gene
Patients with sepsis and other catabolic conditions, such as severe trauma, cancer, and fasting, suffer significant loss of body protein, the majority of which originates from skeletal muscle. Recent evidence suggests that muscle protein breakdown during sepsis is caused by upregulated activity in the ubiquitin-proteasome pathway and is associated with increased expression of the ubiquitin gene.