Open AccessGlutamine Extraction by the Gut Is Reduced in Patients with Depleted Gastrointestinal Cancer
Author(s) -
René R W J van der Hulst,
M.F. von Meyenfeldt,
N.E.P. Deutz,
Peter B. Soeters
Publication year - 1997
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199701000-00013
Subject(s) - glutamine , ileum , medicine , jejunum , colorectal cancer , gastroenterology , intestinal mucosa , small intestine , cancer , biochemistry , biology , amino acid
Glutamine is an important fuel for the intestinal mucosa. However, glutamine pools may become depleted in the cancer-bearing host as a result of tumor consumption and diminished production due to nutritional depletion. As human data are lacking, the authors investigated glutamine extraction by different sites of the human intestine, including tumor and the potential relation with the degree of nutritional depletion.