Open AccessGlutamine as a Regulator of DNA and Protein Biosynthesis in Human Solid Tumor Cell Lines
Author(s) -
Masafumi Wasa,
Barrie P. Bode,
Steve F. Abcouwer,
Cynthia L. Collins,
Kenneth K. Tanabe,
Wiley W. Souba
Publication year - 1996
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199608000-00012
Subject(s) - glutamine , cell growth , cell culture , dna synthesis , biochemistry , amino acid , thymidine , amino acid transporter , transporter , in vitro , cell , biology , gene , genetics
The transport of glutamine by six different human solid tumor-derived cell lines (e.g., breast, colon, liver) was characterized and the impact of glutamine deprivation on rates of tumor cell proliferation and DNA and protein synthesis was assayed.