Open AccessA Role for Tumor Necrosis Factor- α in the Increased Mortality Associated with Vibrio Vulnificus Infection in the Presence of Hepatic Dysfunction
Author(s) -
N. Joseph Espat,
Troy Auffenberg,
Amer Abouhamze,
Julie Baumhofer,
Lyle L. Moldawer,
Richard J. Howard
Publication year - 1996
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199604000-00012
Subject(s) - vibrio vulnificus , medicine , tumor necrosis factor alpha , tumor necrosis factor α , sepsis , necrosis , immunology , bacteria , genetics , biology
The present study was designed to evaluate whether pre-existing hepatic dysfunction (cirrhosis) leads to increased morbidity and mortality, in part through an inappropriate in vivo tumor necrosis factor-alpha response.