Open AccessResults of a Randomized Trial Comparing Sequential Intravenous/Oral Treatment with Ciprofloxacin Plus Metronidazole to Imipenem/Cilastatin for Intra-Abdominal Infections
Author(s) -
Joseph S. Solomkin,
Harald H. Reinhart,
E. Patchen Dellinger,
Jordan D. Bohnen,
Ori D. Rotstein,
Stephen B. Vogel,
Henry S. Simms,
Carol Hill,
H. Stephen Bjornson,
Daniel Haverstock,
Holly Coulter,
Roger Echols
Publication year - 1996
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199603000-00012
Subject(s) - medicine , metronidazole , ciprofloxacin , cilastatin , imipenem/cilastatin , imipenem , randomized controlled trial , trovafloxacin , antibiotics , antibacterial agent , surgery , gastroenterology , antibiotic resistance , microbiology and biotechnology , biology
In a randomized, double-blind, multicenter trial, ciprofloxacin/metronidazole was compared with imipenem/cilastatin for treatment of complicated intra-abdominal infections. A secondary objective was to demonstrate the ability to switch responding patients from intravenous (IV) to oral (PO) therapy.