Open AccessNitric Oxide Regulates Basal But Not Capsaicin-, CGRP-, or Bile Salt-Stimulated Rabbit Esophageal Mucosal Blood Flow
Author(s) -
Lloyd McKie,
Barbara L. Bass,
Brian J. Dunkin,
John W. Harmon
Publication year - 1995
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199508000-00011
Subject(s) - capsaicin , calcitonin gene related peptide , nitric oxide , medicine , phenylephrine , blood flow , calcitonin , endocrinology , neurogenic inflammation , nitric oxide synthase , substance p , pharmacology , neuropeptide , blood pressure , receptor
Esophageal mucosal blood flow is a dynamic phenomenon that is altered by luminal content that probably represents an important intrinsic method of defense. This study investigated the role played by endogenous nitric oxide in the regulation of esophageal mucosal blood flow at rest and in response to luminal capsaicin, a specific stimulant for visceral afferent nerves, as well as calcitonin gene-related peptide, and the bile salt deoxycholate.