Open AccessTreatment of Experimental Human Mesothelioma Using Adenovirus Transfer of the Herpes Simplex Thymidine Kinase Gene
Author(s) -
W. Roy Smythe,
Harry C. Hwang,
Ashraf A. Elshami,
Kunjlata M. Amin,
Stephen L. Eck,
Beverly L. Davidson,
James M. Wilson,
Larry R. Kaiser,
Steven Μ. Albelda
Publication year - 1995
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199507000-00013
Subject(s) - mesothelioma , genetic enhancement , ganciclovir , medicine , thymidine kinase , suicide gene , cancer research , viral vector , herpes simplex virus , in vivo , virology , pathology , immunology , human cytomegalovirus , virus , biology , gene , recombinant dna , biochemistry , microbiology and biotechnology
The authors demonstrate the ability of an adenovirus vector expressing the herpes simplex thymidine kinase (HSVtk) gene to treat human malignant mesothelioma growing within the peritoneal cavity of severe combined immunodeficient (SCID) mice.