Open AccessGlutamine Enhances Selectivity of Chemotherapy Through Changes in Glutathione Metabolism
Author(s) -
K. A. Rouse,
Emmanuel Nwokedi,
Jeffrey Woodliff,
Joshua Epstein,
V. Suzanne Klimberg
Publication year - 1995
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199504000-00014
Subject(s) - medicine , glutamine , glutathione , metabolism , chemotherapy , biochemistry , pharmacology , amino acid , enzyme , chemistry
Chemotherapy doses are limited by toxicity to normal tissues. Intravenous glutamine protects liver cells from oxidant injury by increasing intracellular glutathione (GSH) content. The authors hypothesized that supplemental oral glutamine (GLN) would increase the therapeutic index of methotrexate (MTX) by improving host tolerance through changes in glutathione metabolism. The authors examined the effects of oral glutamine on tumor and host glutathione metabolism and response to methotrexate.