Open AccessPathogenesis of Hemorrhage-Induced Bacteria/Endotoxin Translocation in Rats Effects of Recombinant Bactericidal/Permeability-Increasing Protein
Author(s) -
Yong-ming Yao,
Soheyl Bahrami,
Guenther Leichtfried,
Heinz Redl,
G. Schlag
Publication year - 1995
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199504000-00011
Subject(s) - medicine , pathogenesis , recombinant dna , microbiology and biotechnology , bacteria , bacterial translocation , chromosomal translocation , immunology , biochemistry , gene , biology , chemistry , genetics
This study was conducted to determine the role of gut-derived bacteria/endotoxin in the pathogenesis of the multiple-organ damage and mortality, the possible beneficial effect of recombinant bactericidal/permeability-increasing protein (rBPl21), and whether neutralizing endotoxemia by rBPl21 treatment influences tumor necrosis factor (TNF) formation in rats after hemorrhagic shock and resuscitation.