Open AccessGranulocyte Macrophage Colony-Stimulating Factor Improves Survival in Two Models of Gut-Derived Sepsis by Improving Gut Barrier Function and Modulating Bacterial Clearance
Author(s) -
Roberto Gennari,
J. Wesley Alexander,
Luca Gianotti,
Tonyia Eaves-Pyles,
Sharon Hartmann
Publication year - 1994
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199407000-00010
Subject(s) - sepsis , granulocyte macrophage colony stimulating factor , granulocyte , immunosuppression , immunology , biology , chromosomal translocation , phagocytosis , microbiology and biotechnology , tumor necrosis factor alpha , cytokine , gene , biochemistry
The effect of recombinant murine granulocyte macrophage colony-stimulating factor (rmGM-CSF) on survival and host defense was studied using two clinically relevant models of infection that included transfusion-induced immunosuppression.