Open AccessComparison of Peripheral Blood Leukocyte Kinetics After Live Escherichia coli, Endotoxin, or Interleukin-1 α Administration Studies Using a Novel Interleukin-1 Receptor Antagonist
Author(s) -
A S Hawes,
E. Fischer,
Michael A. Marano,
Kimberly J. Van Zee,
Craig S. Rock,
S F Lowry,
Steve E. Calvano,
Lyle L. Moldawer
Publication year - 1993
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199307000-00013
Subject(s) - medicine , immunology , interleukin 1 receptor antagonist , lipopolysaccharide , cytokine , septic shock , interleukin , receptor antagonist , interleukin 6 , sepsis , microbiology and biotechnology , receptor , biology , antagonist
This study was undertaken to evaluate whether hematologic and immunologic effects observed after bacteremia and endotoxemia in the host could be replicated by administration of recombinant human interleukin-1 alpha (IL-1 alpha) in a primate model. Furthermore, to determine whether endogenously produced interleukin-1 (IL-1) contributes to the changes observed during endotoxemia or gram-negative septic shock, a specific IL-1 receptor antagonist (IL-1 ra) was administered.