Open AccessAxonal Necrosis of Enteric Autonomic Nerves in Continent Heal Pouches Possible Implications for Pathogenesis of Crohnʼs Disease
Author(s) -
Ann M. Dvorak,
Andrew B. Onderdonk,
Robin S. McLeod,
Rita A. Monahan-Earley,
Jim Cullen,
Donald A. Antonioli,
J. E. Blair,
Ellen S. Morgan,
Ronald L. Cisneros,
Patricia Estrella,
Zane Cohen,
William Silen
Publication year - 1993
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199303000-00008
Subject(s) - medicine , pathogenesis , anatomy , pathology
Axonal necrosis was first described in samples of small intestine from patients with Crohn's disease (A.M. Dvorak et al. Hum Pathol 1980; 11:620-634). Clinically evident inflammation of continent ileal reservoirs (pouches) has clinical features that resemble Crohn's disease. Possible similarities in the pathogenesis of Crohn's disease and pouchitis were sought using ultrastructural and microbiologic tools to identify damaged enteric nerves and tissue bacteria.