Open AccessAntibiotic Treatment for Surgical Peritonitis
Author(s) -
Dale M. Mosdell,
Don M. Morris,
Anna Voltura,
David E. Pitcher,
Melvin W. Twiest,
Robert W. Milne,
Brian G. Miscall,
Donald E. Fry
Publication year - 1991
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199111000-00001
Subject(s) - medicine , antibiotics , peritonitis , antibiotic sensitivity , microbiological culture , antibiotic therapy , intensive care medicine , surgery , bacteria , microbiology and biotechnology , genetics , biology
The charts of 480 patients with secondary bacterial peritonitis were reviewed. The antibiotics used were compared with the culture and sensitivity data obtained at surgery, and the outcomes of patients were evaluated. Patients treated with a single broad-spectrum antibiotic had a better outcome than patients treated with multiple drug treatment. Inadequate empiric antibiotic treatment was associated with poorer outcome than any other type of treatment. The outcome of this inadequate treatment group could not be improved by any antibiotic response to culture and sensitivity information after operation. Those patients treated with antibiotic coverage for anticipated organisms and having no cultures taken did as well as patients having cultures taken. Surgeons typically ignore culture data after operation, and only 8.8% of patients in this study had an appropriate change in antibiotic treatment after operation. A benefit from obtaining operative cultures could not be identified.