Open AccessBiliary Response to Glucagon in Humans
Author(s) -
Gene D. Branum,
Bert A. Bowers,
Christopher R. Watters,
Jon E. Haebig,
Giovanni Cucchiaro,
Marwan Farouk,
William C. Meyers
Publication year - 1991
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199104000-00008
Subject(s) - medicine , enterohepatic circulation , glucagon , biliary tract , phospholipid , endocrinology , bile duct , secretion , bile acid , common bile duct , cholesterol , gastroenterology , hormone , biochemistry , biology , membrane
Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.