Open AccessThe Role of Calcium Ions and Calcium Channel Entry Blockers in Experimental Ischemia–Reperfusion-induced Liver Injury
Author(s) -
Russell J. Nauta,
Evangelos C. Tsimoyiannis,
Mario Uribe,
Daniel B. Walsh,
Deborah L. Miller,
Arthur B. Butterfield
Publication year - 1991
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-199102000-00008
Subject(s) - medicine , verapamil , calcium , ischemia , xanthine oxidase , calcium channel , reperfusion injury , mitochondrion , pharmacology , anesthesia , enzyme , endocrinology , biochemistry , chemistry
Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting the xanthine dehydrogenase to xanthine oxidase, the significant mitochondrial calcium loading during the ischemic period, and the potentiation of calcium and oxygen-derived free radicals to promote injury to mitochondria are mechanisms supported by this study, based on both histologic observations and on the pattern of enzyme leak after the acute ischemic event.