Open AccessAntibiotic Prophylaxis in Acute Nonperforated Appendicitis
Author(s) -
Tayla Bauer,
B Vennits,
B Holm,
Jan HahnPedersen,
DENNIS LYSEN,
Hanne Galatius,
E. S. Kristensen,
Peder H. Graversen,
Flemming Wilhelmsen,
H Skjoldborg,
STIG MALMFRED,
JESS VILLADSEN,
Jørgen Bendix
Publication year - 1989
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198903000-00010
Subject(s) - medicine , cefoxitin , antibiotic prophylaxis , appendix , surgery , incidence (geometry) , antibiotics , prospective cohort study , abscess , randomized controlled trial , appendicitis , paleontology , physics , optics , biology , bacteria , microbiology and biotechnology , genetics , staphylococcus aureus
In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.