Open AccessOrthotopic Liver Transplantation for Primary Sclerosing Cholangitis
Author(s) -
J. Wallis Marsh,
Shunzaburo Iwatsuki,
Leonard Makowka,
Carlos O. Esquivel,
Robert D. Gordon,
S. Todo,
Andreas G. Tzakis,
Charles M. Miller,
David Van Thiel,
Thomas E. Starzl
Publication year - 1988
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198801000-00005
Subject(s) - medicine , primary sclerosing cholangitis , liver transplantation , orthotopic liver transplantation , stage (stratigraphy) , liver disease , gastroenterology , incidence (geometry) , medical therapy , transplantation , survival rate , disease , surgery , paleontology , physics , biology , optics
The incidence or diagnostic rate of sclerosing cholangitis is increasing. Because of the lack of effective medical or surgical therapy for patients with end-stage liver disease and sclerosing cholangitis, results with orthotopic liver transplantation were examined. The results of 55 consecutive liver replacements for this disease were reviewed. The 1- and 2-year actuarial survival rates are 71% and 57%, respectively. Orthotopic liver transplantation for end-stage liver disease from sclerosing cholangitis has emerged as the most effective therapy.