Open AccessIncidence of Perforated and Bleeding Peptic Ulcers before and after the Introduction of H2-Receptor Antagonists
Author(s) -
Andreas Christensen,
Richard Bousfield,
John Christiansen
Publication year - 1988
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198801000-00002
Subject(s) - medicine , incidence (geometry) , perforation , peptic ulcer , peptic , gastroenterology , histamine h2 receptor , surgery , population , duodenal ulcer , receptor , antagonist , materials science , physics , environmental health , optics , punching , metallurgy
The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.