Open AccessAdrenergic Control of Adipocyte Lipolysis in Trauma and Sepsis
Author(s) -
Forse Ra,
Rudolph L. Leibel,
Jeffrey Askanazi,
Jules Hirsch,
John M. Kinney
Publication year - 1987
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198712000-00010
Subject(s) - lipolysis , adipocyte , endocrinology , medicine , adrenergic receptor , receptor , sepsis , downregulation and upregulation , adrenergic , in vivo , adipose tissue , biology , biochemistry , microbiology and biotechnology , gene
Adipocyte lipolysis and its adrenergic control were studied in vitro from normal patients and those with trauma and sepsis. The adrenergic receptors were studied in terms of their responsiveness, a measure of the postreceptor mechanism, and their sensitivity, a measure of the receptor number or affinity. With early trauma, beta-adrenergic responsiveness and receptor number were significantly decreased. This is desensitization of the beta-receptors with down regulation and indicates increased in vivo lipolysis in early injury. After 4 days these changes had returned to normal. Early sepsis resulted in a significant increase in beta- and alpha-receptor responsiveness with beta-upregulation. This indicated hypersensitivity of the adipocyte adrenergic receptors and suggests the presence of an in vivo block of the adrenergic receptors in early sepsis. This would decrease adipocyte lipolysis. After 4 days there was a decrease in beta-receptor responsiveness in the patients with sepsis, indicating that the adrenergic receptor block was no longer present and adipocyte adrenergic stimulated lipolysis was increased.