Open AccessCarcinomas Arising in Cystic Conditions of the Bile Ducts
Author(s) -
Ricardo L. Rossi,
Mark L. Silverman,
John W. Braasch,
J. Lawrence Munson,
Stephen G. ReMine
Publication year - 1987
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198704000-00006
Subject(s) - medicine , malignancy , adenocarcinoma , incidence (geometry) , metaplasia , carcinoma , pathology , carcinoma in situ , gastroenterology , choledochal cysts , cyst , cancer , physics , optics
Thirty patients with cystic disease of the bile ducts operated on between 1965 and 1985 were reviewed. Three patients (10%) had a synchronous adenocarcinoma, and in three patients (10%) a metachronous carcinoma developed for a total incidence of malignancy of 20%. All patients died within 1 year of the diagnosis of malignancy. Of 19 benign cysts available for pathologic examination, one third had proliferative epithelial changes, and in two of these patients a metachronous carcinoma developed. Goblet cell metaplasia was prominent in four patients. This suggests the possibility that dysplastic changes and metaplasia of the epithelium could give rise to carcinoma. Resection of benign cysts of the bile ducts is favored, when feasible, in an attempt to decrease the incidence of malignancy.