Open AccessUsefulness of Selective Arterial Secretin Injection Test for Localization of Gastrinoma in the Zollinger-Ellison Syndrome
Author(s) -
Masayuki Imamura,
Kazuhisa Takahashi,
Hideki Adachi,
Souhei Minematsu,
Yutaka Shimada,
Mitsuru Naito,
Takashi Suzuki,
Takayoshi Tobe,
Takeshi Azuma
Publication year - 1987
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198703000-00003
Subject(s) - gastrinoma , secretin , medicine , zollinger ellison syndrome , duodenum , gastrin , pancreas , radiology , nuclear medicine , secretion
Secretin was injected into a feeding or nonfeeding artery of a gastrinoma and blood samples were taken from the hepatic vein (HV) or a peripheral artery (PA) to measure the changes of serum immunoreactive gastrin concentration (IRG). The IRG in the HV rose within 40 seconds and in the PA rose within 60 seconds after the injection of secretin into a feeding artery, but not after secretin was injected into a nonfeeder. These results indicated that secretin directly stimulates a gastrinoma to release gastrin in vivo. The selective arterial secretin injection test (SASI test) was applied in three patients in whom gastrinomas could not be located by computed tomography, ultrasonography, or arteriography, and functioning gastrinomas were located in all three patients. In one patient, malignant gastrinomas in the head of the pancreas and in the duodenum could be resected radically with the help of this test.