Open AccessGastric Autonomic Nerve (GAN) Tumor and Extra-adrenal Paraganglioma in Carneyʼs Triad
Author(s) -
Bartholomew J. Tortella,
Jeffrey B. Matthews,
Donald A. Antonioli,
Ann M. Dvorak,
William Silen
Publication year - 1987
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198703000-00001
Subject(s) - medicine , paraganglioma , stromal tumor , pathology , triad (sociology) , gist , glomus tumor , stromal cell , psychology , psychoanalysis
Carney's Triad comprises a triad of neoplasms: gastric stromal tumor, extra-adrenal paraganglioma (usually functional), and pulmonary chondroma. At least two of these are needed for the presumptive diagnosis of the Triad. This report presents a patient who had resected a gastric tumor and nonfunctional extra-adrenal paraganglioma. The gastric tumor resembled a gastric leiomyosarcoma by light microscopy, but electron microscopy revealed it to be a gastric autonomic nerve (GAN) tumor. Based on this evidence it appears that both the gastric lesions and the paragangliomata of Carney's Triad are tumors of the autonomic nervous system. Thus, the Triad may be a disorder of the autonomic nervous system rather than a multiple endocrine neoplasia syndrome or multiple hamartoma syndrome.