Open AccessPatterns of Failure in Patients with Resected Stage I and II Non-Small-cell Carcinoma of the Lung
Author(s) -
AUTHOR_ID
Publication year - 1987
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198701000-00012
Subject(s) - login , medicine , logo (programming language) , world wide web , register (sociolinguistics) , internet privacy , personally identifiable information , computer science , computer security , philosophy , linguistics , programming language
The pattern of failure was studied in 1012 patients with resected Stage I or II non-small-cell carcinoma of the lung. Initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. The most frequent sites of initial failure were the bronchial resection line (16%) and the central nervous system (CNS) (15%). The site distribution of initial failure does not appear to depend on TNM stage or pattern of nodal involvement. Patients with poorly differentiated disease had a greater rate of initial extrathoracic failure (p less than 0.01), predominantly bone or CNS. Implications for therapy and future research are discussed.