Open AccessWater and Electrolyte Absorption from a Human Thiry-Vella Ileal Loop
Author(s) -
Edward C. S. Lai,
Ronald K. Tompkins
Publication year - 1986
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198604000-00016
Subject(s) - secretin , medicine , glucagon , electrolyte , jejunum , ileum , endocrinology , bicarbonate , absorption (acoustics) , gastrin , hormone , secretion , chemistry , materials science , electrode , composite material
Water and electrolyte flux in response to systemic administration of four different gastrointestinal hormones were studied in a human with a chronic Thiry-Vella ileal loop. Gastrin infusion with a pharmacological dose of 4 micrograms/kg-hr has no effect. Responses to glucagon were proportional to infused doses with directly increased absorption of water and electrolytes (except bicarbonate). However, when gastrin was infused simultaneously with glucagon, the enhanced absorption was inhibited. Secretin only transiently increased absorption of fluid and electrolytes. In contrast to its effects on jejunum, CCK increased both water and electrolyte absorption from the ileum.