Open AccessEffect of Methionine-enkephalin and Naloxone on Bombesin-stimulated Gastric Acid Secretion, Gastric, and Pancreatic Polypeptide Release in the Dog
Author(s) -
A Materia,
Bernard M. Jaffe,
Irvin M. Modlin,
Anthony Sank,
Deborah Albert
Publication year - 1982
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198207000-00011
Subject(s) - medicine , bombesin , endocrinology , (+) naloxone , gastric acid , secretion , pancreatic polypeptide , methionine , pentagastrin , neuropeptide , hormone , amino acid , opioid , receptor , glucagon , biochemistry , chemistry
In four dogs with chronic gastric fistulae, bombesin infusion was used to stimulate the release of gastrin and pancreatic polypeptide (PP) as well as rates of gastric acid secretion. Neither methionine-enkephalin (met-enkephalin) nor naloxone alone or the combination of these agents altered bombesin-stimulated gastrin release. met-enkephalin alone (but not naloxone) significantly inhibited the gastric secretory response to bombesin, but this inhibitory effect was not influenced by the simultaneous infusion of naloxone; the data suggested that the effect of met-enkephalin was indirect, and perhaps modulated by another inhibitory mechanism. Whereas PP release induced by bombesin was not affected by naloxone, it was significantly suppressed by met-enkaphalin; since this inhibition was virtually totally reversed by naloxone, the data suggested that the effect of opiate peptides on the release of pancreatic polypeptide was direct and mediated by a specific opiate receptor.