Open AccessSurvival with Carcinoma Arising in Mucosal Ulcerative Colitis
Author(s) -
Ian C. Lavery,
Richard A. Chiulli,
David G. Jagelman,
Victor W. Fazio,
Frank L. Weakley
Publication year - 1982
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198204000-00021
Subject(s) - medicine , ulcerative colitis , gastroenterology , proctocolectomy , carcinoma , incidence (geometry) , colitis , adenocarcinoma , cancer , colorectal cancer , disease , physics , optics
Adenocarcinoma of the colon is a well-recognized complication of total chronic ulcerative colitis. The incidence increases with time, and the carcinoma arising in chronic ulcerative colitis has developed a bad clinical reputation in terms of aggressive behavior. The survival statistics of patients with cancer arising in chronic ulcerative colitis are compared with statistics for a group of noncolitic patients with equivalent clinicopathologic staging treated at the same institution. When grouped by extended Duke's classification and compared with carcinoma arising without ulcerative colitis, there was no statistical difference in survival rates. The overall results are worse because of a higher percentage of patients with incurable disease at the time of operation. With improved surveillance and methods of detecting premalignant changes, the necessity for prophylactic proctocolectomy should decline.