Open AccessSelection of High Risk Groups Among Prognostically Favorable Patients with Breast Cancer
Author(s) -
Jesper Andersen,
K Fischermann,
Klaus HouJensen,
E Henriksen,
Knud West Andersen,
H Johansen,
H Brincker,
H. T. Mouridsen,
T Castberg,
Niels Nygaard Rossing,
Mikael Rørth
Publication year - 1981
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198107000-00001
Subject(s) - medicine , anaplasia , breast cancer , oncology , prospective cohort study , adjuvant , danish , adjuvant therapy , cancer , surgery , pathology , linguistics , philosophy
In a prospective, nationwide, decentralized breast cancer project conducted by The Danish Breast Cancer Cooperative Group (DBCG) the recurrence rate within the first year after surgery was analysed in relation to tumor anaplasia. One thousand forty-eight patients met the requirements of eligibility, i.e. tumor size less than or equal to 5 cm with negative axillary nodes, and no skin or deep invasion. The recurrence rates in tumors with anaplasia Grades I, II, and III were 4, 9, and 14%, respectively (p = 0.001). Therefore, it seems possible, prospectively, among otherwise prognostically favorable patients, to select a group with high risk of recurrence which might benefit from adjuvant systemic therapy.