Open AccessProspective, Randomized, Double-blind Comparison of Metronidazole and Tobramycin with Clindamycin and Tobramycin in the Treatment of Intra-abdominal Sepsis
Author(s) -
John A. Smith,
A G Skidmore,
A D Forward,
A. M. Clarke,
E. Rand Sutherland
Publication year - 1980
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-198008000-00015
Subject(s) - medicine , tobramycin , clindamycin , metronidazole , double blind , sepsis , double blind study , antibiotics , prospective cohort study , adverse effect , anesthesia , surgery , gentamicin , microbiology and biotechnology , alternative medicine , pathology , biology , placebo
In a prospective, double-blind study, clindamycin was compared with metronidazole, each combined with tobramycin and all by the intravenous route in the treatment of intra-abdominal sepsis. Twenty-three patients received clindamycin and 34 patients received 35 courses of metronidazole. Analysis of the clinical responses of patients indicates that the two antibiotic regiments are of equal efficacy in that there was no difference between them in terms of defervescence or duration of infection. Few adverse effects were noted, and all appeared to be of a minor nature.